AWS c5.4xlargevsAWS c5ad.4xlarge

c5.4xlarge pairs 16 vCPUs with 32GB of RAM at $0.6800/hr On-Demand (about $490/mo at 24×7). c5ad.4xlarge pairs 16 vCPUs with 32GB at $0.6880/hr (~$495/mo). c5.4xlarge is 1% cheaper per hour than c5ad.4xlarge ($0.0080/hr gap).

Both are generation-5 compute-optimized instances, but they run on different silicon: **c5.4xlarge** is Intel Xeon (x86_64), **c5ad.4xlarge** is AMD EPYC (x86_64). AMD variants (suffix `a`) are typically 10% cheaper than Intel siblings at comparable single-thread performance. Graviton variants (suffix `g`) are usually 20–40% cheaper but require ARM64-compatible binaries — most modern Linux stacks are fine, but verify any compiled extensions, native modules, or third-party binaries before migrating. Same vCPU/RAM ratio, same network performance class, different processor.

On raw price-per-performance, the two are c5ad.4xlarge delivers ~39% more single-thread Sysbench score per dollar (1707 vs 2376 points per $1/hr). That's the cleanest signal we have for "which one runs your workload faster per dollar," but it only matters if your workload is single-thread-bound; for parallel workloads the multi-core scores (14285 vs 13803) are what to weigh. Spot pricing flips many of these comparisons — when c5.4xlarge drops to $0.2355/hr and c5ad.4xlarge drops to $0.2844/hr, the cheap-per-hour winner can swing meaningfully.

In practice, pick c5.4xlarge when your workload is closer to compute-optimized (CPU-bound work — batch processing, web servers under sustained load, game servers). Pick c5ad.4xlarge when it's closer to compute-optimized (CPU-bound work — batch processing, web servers under sustained load, game servers). When neither side is obviously right, the cheaper hourly rate usually wins for fault-tolerant batch workloads, while the higher single-core score usually wins for latency-sensitive web traffic. The regional pricing tables linked from each instance page below show where each is currently cheapest — sometimes a >20% regional gap flips the comparison entirely.